{"id":23491,"date":"2025-07-01T15:08:07","date_gmt":"2025-07-01T13:08:07","guid":{"rendered":"https:\/\/elainternational.eu\/?page_id=23491"},"modified":"2025-09-19T12:27:04","modified_gmt":"2025-09-19T10:27:04","slug":"pmd","status":"publish","type":"page","link":"https:\/\/elainternational.eu\/en\/research\/clinical-trials\/pmd\/","title":{"rendered":"PMD"},"content":{"rendered":"\n\n<div class=\"text-ctas container-content\">\n    <h3>Clinical trials<br\/> on Pelizaeus-Merzbacher Disease<\/h3>\n    <div class=\"text\">\n            <\/div>\n    <section class=\"ctas\">\n            <\/section>\n<\/div>\n\n\n\n\n<div class=\"single-button\">\n<div class=\"container-small\">\n    <a href=\"https:\/\/elainternational.eu\/en\/leucodystrophies\/pmd-maladie-de-pelizaeus-merzbacher-et-autres-leucodystrophies-hypomyelinisantes\/\" target=\"\" class=\"btn-primary\">General information on PMD<\/a>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Le Dr. Steffi Dreha-Kulaczewski pr\u00e9sente l&#039;essai clinique Orbit pour le traitement de la PMD\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/ddOhQg29ZiM?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><figcaption class=\"wp-element-caption\"><em>Dr. Steffi Dreha-Kulaczewski &#8211; Families\/Researchers meeting 202<\/em>5<\/figcaption><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n\n<div class=\"block-wrapper\">\n    <div class=\"container-content\">\n        <h3>Orbit trial &#8211; Interventional &#8211; NCT06150716<\/h3>\n<p>Evaluating the safety and tolerability of ION356, an antisense oligonucleotide targeting <i>PLP1<\/i><\/p>\n\n                \n\n                                        <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06150716\" \n                class=\"link-has-icon link-primary\" \n                target=\"_blank\" rel=\"noopener noreferrer\">\n                Clinicaltrial.gov                <\/a>\n            \n                <svg width=\"17\" height=\"14\" viewBox=\"0 0 17 14\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                    <path d=\"M0 7H15M15 7L9.78261 1M15 7L9.78261 13\" stroke=\"#DF156E\" stroke-width=\"2\"><\/path>\n                <\/svg>\n\n                <span>Clinicaltrial.gov<\/span>\n                                \n            <\/a>\n\n\n        \n\n                                        <a href=\"https:\/\/neurology.ionis.com\/our-pipeline\" \n                class=\"link-has-icon link-primary\" \n                target=\"_blank\" rel=\"noopener noreferrer\">\n                Ionis website                <\/a>\n            \n                <svg width=\"17\" height=\"14\" viewBox=\"0 0 17 14\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                    <path d=\"M0 7H15M15 7L9.78261 1M15 7L9.78261 13\" stroke=\"#DF156E\" stroke-width=\"2\"><\/path>\n                <\/svg>\n\n                <span>Ionis website<\/span>\n                                \n            <\/a>\n\n\n                    <\/div>\n<\/div>\n\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:45px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<style>\n    .separateur {\n        height: 20px;\n        background-color: #F5B6D2;\n    }\n<\/style>\n\n<div id=\"maj\" class=\"separateur-container container-content\">\n    <div class=\"separateur\"><\/div>\n<\/div>\n\n\n\n<div style=\"height:45px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Le Dr. Steffi Dreha-Kulaczewski pr\u00e9sente l&#039;essai clinique Rocket sur la PMD\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/gXweh5xYzvA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><figcaption class=\"wp-element-caption\"><em><em><em>Dr. Steffi Dreha-Kulaczewski &#8211; Families\/Researchers meeting 202<\/em>5<\/em><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n\n<div class=\"block-wrapper\">\n    <div class=\"container-content\">\n        <h3>Rocket trial &#8211; Observational &#8211; NCT05659901<\/h3>\n<p>Study on the natural history of PMD<\/p>\n\n                \n\n                                        <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05659901\" \n                class=\"link-has-icon link-primary\" \n                target=\"_blank\" rel=\"noopener noreferrer\">\n                Clinicaltrial.gov                <\/a>\n            \n                <svg width=\"17\" height=\"14\" viewBox=\"0 0 17 14\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                    <path d=\"M0 7H15M15 7L9.78261 1M15 7L9.78261 13\" stroke=\"#DF156E\" stroke-width=\"2\"><\/path>\n                <\/svg>\n\n                <span>Clinicaltrial.gov<\/span>\n                                \n            <\/a>\n\n\n        \n\n                                        <a href=\"https:\/\/neurology.ionis.com\/our-pipeline\" \n                class=\"link-has-icon link-primary\" \n                target=\"_blank\" rel=\"noopener noreferrer\">\n                Ionis website                <\/a>\n            \n                <svg width=\"17\" height=\"14\" viewBox=\"0 0 17 14\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                    <path d=\"M0 7H15M15 7L9.78261 1M15 7L9.78261 13\" stroke=\"#DF156E\" stroke-width=\"2\"><\/path>\n                <\/svg>\n\n                <span>Ionis website<\/span>\n                                \n            <\/a>\n\n\n                    <\/div>\n<\/div>\n\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":6,"featured_media":0,"parent":23488,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-23491","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PMD - ELA International<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/elainternational.eu\/en\/research\/clinical-trials\/pmd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PMD - ELA International\" \/>\n<meta property=\"og:url\" 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