{"id":20815,"date":"2024-06-25T09:39:58","date_gmt":"2024-06-25T07:39:58","guid":{"rendered":"https:\/\/ela-international.preprod.melisagency.fr\/?post_type=news_research&#038;p=20815"},"modified":"2024-07-11T15:17:12","modified_gmt":"2024-07-11T13:17:12","slug":"megalencephalic-leukoencephalopathy-with-subcortical-cysts-is-an-astrocyte-disease-of-the-neurovascular-unit","status":"publish","type":"news_research","link":"https:\/\/elainternational.eu\/en\/actualites_recherche\/megalencephalic-leukoencephalopathy-with-subcortical-cysts-is-an-astrocyte-disease-of-the-neurovascular-unit\/","title":{"rendered":"Megalencephalic leukoencephalopathy with subcortical cysts is an astrocyte disease of the neurovascular unit"},"content":{"rendered":"\n\n<section class=\"contenus-titre-texte\">\n    <div class=\"contenus-titre-texte-container container-content\">\n        <div class=\"contenus-titre-texte-header mobile-flex-display\">\n                        <h3><strong>Megalencephalic leukoencephalopathy with subcortical cysts is an astrocyte disease of the neurovascular unit<\/strong><\/h3>\n                                <\/div>\n            <\/div>\n<\/section>\n\n\n<section class=\"infos-ribbon\">\n    <div class=\"infos-ribbon-container container-content mobile-flex-display\">\n        <p><em>Martine Cohen-Salmon &#8211; Interdisciplinary Biology Research Center (CIRB), Coll\u00e8ge de France, Paris, France and Denis Vivien &#8211; Hospital Center of the University of Caen Normandie, France and Xavier Decl\u00e8ves &#8211; Inserm UMR-S1144. Faculty of Pharmacy of<br \/>\r\nParis, France &#8211; ELA2019\u2010010C4<\/em><\/p>\n            <\/div>\n<\/section>\n\n\n\n\n\n<section class=\"contenus-titre-texte\">\n    <div class=\"contenus-titre-texte-container container-content\">\n        <div class=\"contenus-titre-texte-header mobile-flex-display\">\n                        <h5><strong>Description of the project<\/strong><\/h5>\n                                <\/div>\n                    <div class=\"contenu-texte\">\n                <p>MLC is a rare form of leukodystrophy mainly linked to mutations in the <em>MLC1 <\/em>gene. Patients with this disease suffer from macrocephaly and motor and cognitive symptoms associated with a progressive myelin degeneration. Why the absence of MLC1 leads to these defects is an open question. MLC1 is a molecule produced by astrocytes, which are the major glial cells of the brain and is enriched at their interface with the blood vessels. Since astrocytes control vascular functions in the brain, we proposed that brain vascular pathological mechanims could be involved in MLC, a question that has never been adressed. Using a mouse model deficient for MLC1, we started to uncover a gliovascular pathology in MLC. Our results suggest that it might be the first pathological sign of MLC. We now propose to further explore these vascular alterations with the underlying idea that knowing their causative mechanisms could provide therapeutic options for MLC patients.<\/p>\n<p style=\"font-weight: 400;\">Project financed by ELA up to: 67 500 \u20ac<\/p>\n            <\/div>\n            <\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"template":"","news_research_categories":[127],"news_research_tags":[114,118],"class_list":["post-20815","news_research","type-news_research","status-publish","hentry","news_research_categories-project","news_research_tags-leukodystrophy","news_research_tags-megalencephalic-leukoencephalopathy-with-subcortical-cysts-mlc"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Megalencephalic leukoencephalopathy with subcortical cysts is an astrocyte disease of the neurovascular unit - ELA International<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/elainternational.eu\/en\/actualites_recherche\/megalencephalic-leukoencephalopathy-with-subcortical-cysts-is-an-astrocyte-disease-of-the-neurovascular-unit\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Megalencephalic leukoencephalopathy with subcortical cysts is an astrocyte disease of the neurovascular unit - ELA International\" \/>\n<meta property=\"og:url\" content=\"https:\/\/elainternational.eu\/en\/actualites_recherche\/megalencephalic-leukoencephalopathy-with-subcortical-cysts-is-an-astrocyte-disease-of-the-neurovascular-unit\/\" \/>\n<meta property=\"og:site_name\" content=\"ELA International\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-11T13:17:12+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/elainternational.eu\\\/en\\\/actualites_recherche\\\/megalencephalic-leukoencephalopathy-with-subcortical-cysts-is-an-astrocyte-disease-of-the-neurovascular-unit\\\/\",\"url\":\"https:\\\/\\\/elainternational.eu\\\/en\\\/actualites_recherche\\\/megalencephalic-leukoencephalopathy-with-subcortical-cysts-is-an-astrocyte-disease-of-the-neurovascular-unit\\\/\",\"name\":\"Megalencephalic leukoencephalopathy with subcortical cysts is an astrocyte disease of the neurovascular unit - 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