{"id":20793,"date":"2024-06-24T16:45:39","date_gmt":"2024-06-24T14:45:39","guid":{"rendered":"https:\/\/ela-international.preprod.melisagency.fr\/?post_type=news_research&#038;p=20793"},"modified":"2024-07-11T11:47:26","modified_gmt":"2024-07-11T09:47:26","slug":"deciphering-disease-heterogeneity-spatiotemporal-analysis-of-molecular-and-cellular-pathology-in-hbsl","status":"publish","type":"news_research","link":"https:\/\/elainternational.eu\/en\/actualites_recherche\/deciphering-disease-heterogeneity-spatiotemporal-analysis-of-molecular-and-cellular-pathology-in-hbsl\/","title":{"rendered":"Deciphering disease heterogeneity: Spatiotemporal analysis of molecular and cellular pathology in HBSL"},"content":{"rendered":"\n\n<section class=\"contenus-titre-texte\">\n    <div class=\"contenus-titre-texte-container container-content\">\n        <div class=\"contenus-titre-texte-header mobile-flex-display\">\n                        <h3><strong>Deciphering disease heterogeneity: Spatiotemporal analysis of molecular and cellular pathology in HBSL<\/strong><\/h3>\n                                <\/div>\n            <\/div>\n<\/section>\n\n\n<section class=\"infos-ribbon\">\n    <div class=\"infos-ribbon-container container-content mobile-flex-display\">\n        <p><em>Ernst Wolvetang et Mohammed Shaker &#8211; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane City , Australia- ELA2021\u2010024F2 (Fellow)<\/em><\/p>\n            <\/div>\n<\/section>\n\n\n\n\n\n<section class=\"contenus-titre-texte\">\n    <div class=\"contenus-titre-texte-container container-content\">\n        <div class=\"contenus-titre-texte-header mobile-flex-display\">\n                        <h5><strong>Description of the project<\/strong><\/h5>\n                                <\/div>\n                    <div class=\"contenu-texte\">\n                <p>In Hypomyelination with Brain stem and Spinal cord involvement and Leg spasticity (HBSL), the rate and degree of spread of symptoms throughout the body are linked to survival outcome. However, the cause for the pathology in HBSL is unknown. Using mini 3D brain oligodendrocytes generated from HBSL patient skin cells, we will study how interactions between oligodendrocytes and their support cells (neurons, astrocytes, and microglia) might lead to the development of disease over time. We will apply the cutting-edge technology of spatial transcriptomics to generate \u201ccell-to-cell network maps\u201d to inform whether we can manipulate cell networks to prevent demyelination. Finally, this research project aims to test nutraceutical supplementation as a therapeutic potential to ameliorate and or reverse established HBSL pathology.<\/p>\n<p style=\"font-weight: 400;\">Project financed by ELA up to:\u00a065 846 \u20ac<\/p>\n            <\/div>\n            <\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"template":"","news_research_categories":[127],"news_research_tags":[113,114],"class_list":["post-20793","news_research","type-news_research","status-publish","hentry","news_research_categories-project","news_research_tags-hbsl-en","news_research_tags-leukodystrophy"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Deciphering disease heterogeneity: Spatiotemporal analysis of molecular and cellular pathology in HBSL - ELA International<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/elainternational.eu\/en\/actualites_recherche\/deciphering-disease-heterogeneity-spatiotemporal-analysis-of-molecular-and-cellular-pathology-in-hbsl\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Deciphering disease heterogeneity: Spatiotemporal analysis of molecular and cellular pathology in HBSL - 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