{"id":20789,"date":"2024-05-29T21:37:08","date_gmt":"2024-05-29T19:37:08","guid":{"rendered":"https:\/\/ela-international.preprod.melisagency.fr\/?post_type=news_research&#038;p=20789"},"modified":"2024-07-11T11:30:00","modified_gmt":"2024-07-11T09:30:00","slug":"anatomy-and-cell-biology-university-of-illinois-at-chicago","status":"publish","type":"news_research","link":"https:\/\/elainternational.eu\/en\/actualites_recherche\/anatomy-and-cell-biology-university-of-illinois-at-chicago\/","title":{"rendered":"Anatomy and Cell Biology University of Illinois at Chicago"},"content":{"rendered":"\n\n<section class=\"contenus-titre-texte\">\n    <div class=\"contenus-titre-texte-container container-content\">\n        <div class=\"contenus-titre-texte-header mobile-flex-display\">\n                        <h3><strong>Anatomy and Cell Biology University of Illinois at Chicago<\/strong><\/h3>\n                                <\/div>\n            <\/div>\n<\/section>\n\n\n<section class=\"infos-ribbon\">\n    <div class=\"infos-ribbon-container container-content mobile-flex-display\">\n        <p><em>Ernesto Bongarzone &#8211; Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, USA- ELA2021\u2010002I2<\/em><\/p>\n            <\/div>\n<\/section>\n\n\n\n\n\n<section class=\"contenus-titre-texte\">\n    <div class=\"contenus-titre-texte-container container-content\">\n        <div class=\"contenus-titre-texte-header mobile-flex-display\">\n                        <h5><strong>Description of the project<\/strong><\/h5>\n                                <\/div>\n                    <div class=\"contenu-texte\">\n                <p>This project will test a new small molecule that is designed to reduce the activity of the enzyme acid ceramidase, which is the enzyme that synthesizes psychosine. Psychosine is a lipid that accumulates to high levels in the brain of Krabbe disease, a genetic disorder caused by deficiency of another enzyme called GALC, which controls the degradation of psychosine. In the absence of GALC activity, psychosine continues to be produced but not degraded. High levels of psychosine in Krabbe disease cause neuropathology and motor and cognitive declines in infants, juvenile and adult patients. There is no cure for Krabbe disease. Here we will treat animal models of infantile and adult onset Krabbe disease with the small compound singly and in combination with a gene therapy approach to restore the activity of the enzyme GALC, which is deficient in Krabbe disease. We hypothesize that reducing the synthesis of psychosine will improve the metabolism of psychosine, reduce disease burden and neuropathology.<\/p>\n<p style=\"font-weight: 400;\">Project financed by ELA up to:\u00a0100 000 \u20ac<\/p>\n            <\/div>\n            <\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"template":"","news_research_categories":[127],"news_research_tags":[129,114],"class_list":["post-20789","news_research","type-news_research","status-publish","hentry","news_research_categories-project","news_research_tags-krabbe-disease","news_research_tags-leukodystrophy"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Anatomy and Cell Biology University of Illinois at Chicago - ELA International<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/elainternational.eu\/en\/actualites_recherche\/anatomy-and-cell-biology-university-of-illinois-at-chicago\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Anatomy and Cell Biology University of Illinois at Chicago - 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